Study population may differ substantially from North America, however
MedPage Today
Date: June 25, 2020
By: Diana Swift, Contributing Writer
Inflammatory bowel disease (IBD) was associated with more than double the risk of dementia, particularly Alzheimer disease, a Taiwan population study found. Furthermore, individuals with IBD were diagnosed with dementia an average of 7 years earlier than non-IBD controls.
Among the study's findings:
- HR 2.54 for dementia in IBD patients versus controls (95% CI 1.91-3.37)
- Dementia incidence 5.5% in IBD patients versus 1.4% in controls (P<0.001)
- Dementia diagnosed in the IBD group at a mean age of 76 vs 83 for controls
- Greatest increase in IBD-related dementia risk for Alzheimer disease, at HR 6.19
On the other hand, no difference in dementia risk was seen by sex, IBD type, or individual IBD medications, but risk appeared to accelerate with disease duration, reported Yen-Po Wang, MD, of Taipei Veterans General Hospital, and colleagues writing online in Gut.
The group used the Taiwanese National Health Insurance Research Database to compare 1,742 IBD patients, diagnosed from 1998 to 2011, with 17,420 controls to assess dementia risk after IBD diagnosis. Participants in both groups were on average just over 60 years old and 51% were men. [FULL STORY]
